Notable Books: The 2011 Selection of Titles and The Reading List 2011. Both lists are geared towards adults, but mature teens can probably find something of interest. Notable Books is just a list of fiction, nonfiction, and poetry, while the Reading List is organized by fiction genre. Both lists are annotated, and the Reading List also includes other suggestions for reading.
I can say, as a librarian, that Emma Donoghue's Room and Rebecca Skloot's The Immortal Life of Henrietta Lacks are still in demand even though they've been out for months. They must be very good books, so if you need something to read on vacation see if your library has copies available.