Mashable recently blogged about the new and improved MapQuest. They include screenshots if you want to take a quick look. If you want to try it out for yourself, head over to the new MapQuest Maps.
I used to use MapQuest all the time, but at some point it became easier to use Google Maps, probably because I was using Google for searching anyway. The new MapQuest looks a lot like Google Maps with a few tweaks. You type your address into the box on the left, then the map on the right shows you where you're going. You can see a satellite view or a 360-degree view (if it's available for that area). You can email the map or post it to Facebook or Twitter.
One neat thing is the menu of options at the top of the map. Choose from icons such as hotels, parking garages, dry cleaners, ATMs, shopping centers, and lots more. Each one you select then becomes a tab above the searching area for easy management.
Give it a try!